| UniProtKB AC (Name) | UniProtKB Section | Organism | Description | |
|---|---|---|---|---|
| B7Z031 (PESTE_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Protein peste; | |
| Q8I8V0 (TAD2B_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Transcriptional adapter 2B; dADA2b; | |
| Q9VQX4 (PNCB_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Nicotinate phosphoribosyltransferase; | |
| Q9VVB4 (CCD22_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Coiled-coil domain-containing protein 22 homolog; | |
| E1JI63 (SNMP2_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Sensory neuron membrane protein 2; | |
| Q9Y123 (RFT1_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Protein RFT1 homolog; | |
| Q9V3S0 (CP4G1_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Cytochrome P450 4g1; CYPIVG1; | |
| Q94545 (ASH2_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Set1/Ash2 histone methyltransferase complex subunit ASH2; Absent, small, or homeotic discs protein 2; | |
| Q8MKJ4 (OB57B_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | General odorant-binding protein 57b; | |
| P09040 (DSK_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Drosulfakinins; Drosulfakinin-0; DSK-0; Drosulfakinin-1; Drosulfakinin I; DSK-I; Drosulfakinin-2; Drosulfakinin II; DSK-II; | |
| Q9VF08 (TIM16_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Mitochondrial import inner membrane translocase subunit Tim16; Protein black pearl; | |
| Q8INQ7 (KTAP2_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Protein KRTCAP2 homolog; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2; | |
| P29615 (LYSP_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Lysozyme P; 1,4-beta-N-acetylmuramidase P; | |
| Q23970 (PBP6_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Pheromone-binding protein-related protein 6; Odorant-binding protein OS-E; | |
| P11449 (VTU1_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Vitelline membrane protein Vm26Aa; Protein SV17.5; Protein TU-2; | |
| Q9VJS7 (PBURS_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Partner of bursicon; Bursicon subunit beta; | |
| P08985 (H2AV_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Histone H2A.v; H2A.F/Z; | |
| P12613 (TCPA_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | T-complex protein 1 subunit alpha; CCT-alpha; Chaperonin containing TCP1 subunit 1; | |
| Q9VGC7 (EI3D2_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Eukaryotic translation initiation factor 3 subunit D-2; Eukaryotic translation initiation factor 3 subunit 7-2; | |
| Q7K4W1 (CDKAL_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Threonylcarbamoyladenosine tRNA methylthiotransferase; CDKAL1-like protein; tRNA-t(6)A37 methylthiotransferase; | |
| Q9VQZ6 (ELP3_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Elongator complex protein 3; tRNA uridine(34) acetyltransferase; | |
| P00528 (SRC64_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Tyrosine-protein kinase Src64B; | |
| P35381 (ATPA_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | ATP synthase subunit alpha, mitochondrial; Protein bellwether; | |
| Q9VJS8 (ELBOW_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Zinc finger protein Elbow; | |
| Q2PE14 (ZCHC8_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Zinc finger CCHC domain-containing protein 8 homolog; | |
| Q9VN45 (SPART_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Protein spartin; | |
| Q9V6D6 (CP301_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Probable cytochrome P450 301a1, mitochondrial; CYPCCCIA1; | |
| P21750 (SALA_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Protein spalt-accessory; Protein spalt-adjacent; | |
| Q9VAJ4 (OB99A_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | General odorant-binding protein 99a; | |
| Q8IPM8 (CPLX_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Complexin; | |
| P37161 (LYSX_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Lysozyme X; 1,4-beta-N-acetylmuramidase X; | |
| Q9W5P1 (MED21_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Mediator of RNA polymerase II transcription subunit 21; Mediator complex subunit 21; dMED21; dSRB7; dTRAP19; | |
| Q8IN41 (TOTX_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Protein Turandot X; | |
| Q8IA41 (GLT11_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Putative inactive polypeptide N-acetylgalactosaminyltransferase 11; Inactive UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11; Inactive protein-UDP acetylgalactosaminyltransferase 11; | |
| Q8MYY6 (GLT13_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Putative polypeptide N-acetylgalactosaminyltransferase 13; Protein-UDP acetylgalactosaminyltransferase 13; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13; | |
| P52029 (G6PI_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Glucose-6-phosphate isomerase; Phosphoglucose isomerase; Phosphohexose isomerase; | |
| Q9W462 (UBP30_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Ubiquitin carboxyl-terminal hydrolase 30 homolog; Deubiquitinating enzyme 30 homolog; Ubiquitin thioesterase 30 homolog; Ubiquitin-specific-processing protease 30 homolog; | |
| Q9VLK8 (PIRAG_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Zinc finger protein piragua; Zinc finger protein fu2; | |
| Q9NFP1 (VNNL1_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Vanin-like protein 1; | |
| P20349 (JANB_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Sex-regulated protein janus-B; | |
| Q08694 (LYSB_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Lysozyme B; 1,4-beta-N-acetylmuramidase B; | |
| Q9VHT9 (NAZO_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Protein Nazo; | |
| P48159 (RL23_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Large ribosomal subunit protein uL14; 60S ribosomal protein L23; L17A; | |
| P37159 (LYSE_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Lysozyme E; 1,4-beta-N-acetylmuramidase E; | |
| P37160 (LYSS_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Lysozyme S; 1,4-beta-N-acetylmuramidase S; | |
| P83972 (LYSD_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Lysozyme D; 1,4-beta-N-acetylmuramidase D; | |
| P10735 (RT12_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Small ribosomal subunit protein uS12m; 40S ribosomal protein S12, mitochondrial; MT-RPS12; Protein technical knockout locus; | |
| Q9VUY9 (PGM_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Phosphoglucomutase; Glucose phosphomutase; | |
| Q9VWN5 (MINY3_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Ubiquitin carboxyl-terminal hydrolase MINDY-3 homolog; Deubiquitinating enzyme MINDY-3; Protein CARP homolog; | |
| Q9VCK0 (EI3D1_DROME) | Swiss-Prot | Drosophila melanogaster (Fruit fly) | Eukaryotic translation initiation factor 3 subunit D-1; Eukaryotic translation initiation factor 3 subunit 7-1; Eukaryotic translation initiation factor 3 subunit p66; |
Drosophila melanogaster is a species of fruit fly in the family Drosophilidae. The species is known generally as the common fruit fly or vinegar fly. D. melanogaster is commonly considered a pest due to its tendency to infest habitations and establishments where fruit is found; the flies may collect in homes, restaurants, stores, and other locations.
Starting with Charles W. Woodworth's proposal of the use of this species as a model organism, D. melanogaster continues to be widely used for biological research in studies of genetics, physiology, microbial pathogenesis, and life history evolution. It is typically used because it is an animal species that is easy to care for, has four pairs of chromosomes, breeds quickly, and lays many eggs.
The genome of D. melanogaster was first sequenced in 2000.
From left to right: i) The number of proteins in the reference proteome of Drosophila melanogaster, ii) the number of unique protein sequences for which at least one model is available, iii) the total number of models and iv) a coverage bar plot is shown.
The bar plot shows the coverage for every protein in the reference proteome of Drosophila melanogaster for which there is at least one model. Different colours (dark green to red boxes) represent the coverage of the targets. Targets with high coverage are represented in dark green (more than 80% of the target's length is covered by models), whereas low coverage is shown in red. The size of each box is proportional to the number of target sequences with a given coverage.
For information on the latest proteome for Drosophila melanogaster, please visit UniProtKB.
You can easily download the latest protein sequences for Drosophila melanogaster proteome here. Please note this download is for the current UniProtKB release, which may be different to release 2024_02 that was used for the most up to date SWISS-MODEL Repository.
| Proteins in proteome | Sequences modelled | Models |
| 13,824 | 10,048 | 19,722 |
Detailed coverage numbers are obtained by hovering the mouse over one of the boxes.
The plot shows the evolution over years (x-axis) of the fraction of Drosophila melanogaster reference proteome residues (y-axis) for which structural information is available. Different colors (light blue to dark blue) in the plot represent the quality of the sequence alignment between the reference proteome sequences (targets) and the sequences of the proteins in the structure database (templates). Alignments with low sequence identity are displayed in light blue, whereas alignments with high sequence identity are depicted in dark blue. The SWISS-MODEL Template Library is used as database of templates. Only target-template alignments found by HHblits and only residues with atom coordinates are considered.
This chart shows the percentage of residues in the Drosophila melanogaster proteome which are covered by experimental structures and the enhancement of coverage by homology modelling by the SWISS-MODEL pipeline. Experimental residue coverage is determined using SIFTS mapping. For residues which are not covered by experimental structures (including where there are no atom records in SIFTS mapping) the model coverage bars are coloured by QMEANDisCo local quality score.
Many proteins form oligomeric structures either by self-assembly (homo-oligomeric) or by assembly with other proteins (hetero-oligomeric) to accomplish their function. In SWISS-MODEL Repository, the quaternary structure annotation of the template is used to model the target sequence in its oligomeric form. Currently our method is limited to the modelling of homo-oligomeric assemblies. The oligomeric state of the template is only considered if the interface is conserved.
| Single Chain | 2-mer | 3-mer | 4-mer | 5-mer | 6-mer | 7-mer | 8-mer | 9-mer | 10-mer | 12-mer | 14-mer | 16-mer | 18-mer | 24-mer | 25-mer | 32-mer | 34-mer | 36-mer | 40-mer | 48-mer | 55-mer | 60-mer | 62-mer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 17,324 | 1,633 | 126 | 440 | 25 | 86 | 10 | 16 | 2 | 11 | 10 | 4 | 8 | 1 | 9 | 1 | 2 | 1 | 1 | 7 | 2 | 1 | 1 | 1 |